Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Acne. Current pathophysiologic considerations].

K Degitz1, F Ochsendorf

  • 1Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität Müchen, München, Deutschland. Klaus.Degitz@lrz.uni-muenchen.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 20, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developments and challenges in dermatology: an update from the Interactive Derma Academy (IDeA) 2019.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

[Andrology in oncological diseases].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2018
Same author

[Acne and rosacea in pregnancy].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2017
Same author

The erbium:YAG Laser: a new technique for the treatment of scrotal calcinosis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same author

European evidence-based (S3) guideline for the treatment of acne - update 2016 - short version.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same author

[Cutaneous changes in long-standing erythropoietic protoporphyria].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2016
Same journal

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
Same journal

[Viral infections of the skin].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
Same journal

[Viral exanthems in children].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
Same journal

[Erratum to: Digital health applications and data protection].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
Same journal

[Virus-induced exanthems in returning travellers].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
Same journal

[Venous ulcus cruris-Surgical treatment].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022
See all related articles

Acne involves seborrhea, follicular hyperkeratosis, and inflammation, often exacerbated by Propionibacterium acnes. Dietary factors and hormonal imbalances also significantly contribute to acne development and severity.

Area of Science:

  • Dermatology
  • Microbiology
  • Immunology

Context:

  • Acne vulgaris pathogenesis involves multifactorial elements including seborrhea, follicular hyperkeratosis, Propionibacterium acnes proliferation, and inflammatory responses.
  • Sebum production, influenced by androgens, and follicular hyperkeratosis, potentially linked to linoleic acid deficiency and inflammatory mediators like interleukin-1, are key contributors.
  • Metabolic byproducts of P. acnes, such as lipases and proteases, trigger perifollicular inflammation, a crucial factor in acne lesion formation and progression.

Purpose:

  • To elucidate the complex interplay of factors contributing to acne pathogenesis.
  • To highlight the roles of microbial activity, host inflammatory responses, and hormonal influences in acne development.
  • To underscore the significance of dietary factors in the initiation and course of acne.

Related Experiment Videos

Summary:

  • Acne pathogenesis is driven by seborrhea, follicular hyperkeratosis, Propionibacterium acnes, and inflammation.
  • Increased sebum and follicular hyperkeratosis promote P. acnes growth, leading to inflammation and abscesses.
  • Androgen levels, linoleic acid, inflammatory mediators (e.g., interleukin-1), and bacterial products contribute to acne pathology.

Impact:

  • Understanding these pathogenic factors provides a basis for targeted therapeutic strategies for acne.
  • Recognizing the role of inflammation and microbial factors can lead to novel anti-acne treatments.
  • The emerging link between diet and acne suggests potential for dietary modifications in acne management.