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03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic gastroenteritis.
Seema Khan1, Susan R Orenstein
1Thomas Jefferson University Medical School, Division of Pediatric Gastroenterology and Nutrition, Alfred I. DuPont Hospital for Children, Wilmington, DE 19803, USA. sekhan@nemours.org
Gastroenterology Clinics of North America
|May 24, 2008
Summary
Eosinophilic gastroenteritis involves eosinophil buildup in the stomach or small intestine, often linked to allergies. Diagnosis requires high suspicion and confirmation of gastrointestinal eosinophilia.
Area of Science:
- Gastroenterology
- Immunology
- Allergy
Background:
- Eosinophilic gastroenteritis is a rare condition.
- Characterized by eosinophilic infiltration of the stomach or small intestine.
- Presents with variable clinical manifestations due to diverse organ involvement and wall depth.
Purpose of the Study:
- To define eosinophilic gastroenteritis.
- To highlight diagnostic challenges and criteria.
- To review current and emerging treatment strategies.
Main Methods:
- Diagnosis relies on identifying significant gastrointestinal eosinophilia.
- Association with atopy is frequently observed.
- Th-2 proinflammatory cytokine profiles support the role of immune responses in animal models.
Main Results:
- Heterogeneous clinical presentations are common.
- Strong association with atopy is noted.
- Intense gastrointestinal eosinophilia is the diagnostic hallmark.
Conclusions:
- Eosinophilic gastroenteritis requires a high index of suspicion for diagnosis.
- Management involves allergen avoidance and anti-inflammatory drugs.
- Biologic therapies and targeted anti-eosinophil agents represent future treatment avenues.
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