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Enteric autoantibodies and gut motility disorders
Purna Kashyap1, Gianrico Farrugia
1Mayo Clinic, Rochester, MN 55905, USA.
Gastroenterology Clinics of North America
|May 24, 2008
Summary
Circulating antibodies are linked to gastrointestinal motility disorders. This review explores antibody types, their significance, and diagnostic/treatment strategies for these conditions.
Area of Science:
- Immunology
- Gastroenterology
- Neurology
Background:
- Gastrointestinal motility disorders can be associated with specific circulating antibodies.
- Anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) is a known marker for paraneoplastic motility disorders.
- Distinct autoantibody profiles are also linked to non-paraneoplastic motility disorders.
Purpose of the Study:
- To review the types of antibodies implicated in gastrointestinal motility disorders.
- To discuss the clinical significance of these autoantibodies.
- To propose diagnostic and treatment algorithms for affected patients.
Main Methods:
- Literature review of studies on antibodies and gastrointestinal motility disorders.
- Analysis of antibody targets and their association with paraneoplastic and non-paraneoplastic conditions.
- Development of clinical work-up and management strategies.
Main Results:
- Identification of various autoantibodies targeting different molecular structures in gastrointestinal motility disorders.
- Correlation between specific autoantibody profiles and disease etiology (paraneoplastic vs. non-paraneoplastic).
- Evidence supporting the role of antibodies in disease pathogenesis.
Conclusions:
- Circulating antibodies are important biomarkers in a subset of gastrointestinal motility disorders.
- Understanding autoantibody profiles aids in diagnosis and management.
- Proposed algorithms can guide clinical practice for patients with antibody-associated motility disorders.
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