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[Experimental study of prostheses modified by three dimensions porous Ti combined bone morphogenetic proteins]
Zhong-Li Li1, Yan Wang, Guo-Qiang Zhang
1Department of Orthopaedics, General Hospital of People's Liberation Army, Beijing 100853, China.
Objective:
To observe bone ingrowth of artificial femur which three dimensions (3-D) porous Ti combined bone morphogenetic proteins (BMPs) integrating on the prostheses surface in dogs.
Methods:
The prostheses integrated 3-D porous Ti on the surface, which combined BMPs directly or through FG, were implanted canine. And fluorescent labeling was done at 2, 5 weeks after that, and then the prostheses with femurs were taken out in 3, 6 weeks after operation. These specimens were treated, then observed through microscopy.
Results:
At 3 weeks, bone growing 1/2 of full thickness in 3-D porous Ti, but bone growing full thickness in 3-D porous Ti at 6 weeks. Bone formation was obviously higher at 6 weeks than at 3 weeks.
Conclusion:
The prostheses modified 3-D porous Ti can accelerate osteogenesis and improve bone formation so that mechanical interlock and integration can be come true.
