Related Experiment Video
Updated: Jul 4, 2026
07:48
Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models
Published on: November 21, 2015
Puma: mauling the intestinal crypt
1School of Biosciences, Cardiff University, CF10 3US, UK. clarkear@cardiff.ac.uk
Cell Stem Cell
|June 5, 2008
Abstract:
Cancer therapies utilizing chemotherapy or radiotherapy are constrained by risk of intestinal stem cell death. In this issue of Cell Stem Cell, Qiu et al. report that Puma deletion prevents intestinal degeneration following DNA damage, thus offering a target protein for the design of enhanced cancer treatments.
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