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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Jul 4, 2026

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
08:36

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

Assessing transneuronal dysfunction utilizing manganese-enhanced MRI (MEMRI).

Faridis Serrano1, Mitchell Deshazer, Karen D B Smith

  • 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Magnetic Resonance in Medicine
|June 27, 2008
PubMed
Summary
This summary is machine-generated.

Manganese-enhanced MRI (MEMRI) can track neuronal function changes using the manganese transfer index (MTI). This method detected alterations in mouse models and with pharmacological treatments, showing its potential for disease research.

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Area of Science:

  • Neuroscience
  • Medical Imaging

Background:

  • Neuronal function assessment is crucial for understanding brain disorders.
  • Manganese-enhanced MRI (MEMRI) offers a potential method for in vivo neuronal activity tracking.

Purpose of the Study:

  • To evaluate the manganese transfer index (MTI) as a measure of in vivo transneuronal efficiency.
  • To assess the MTI's utility in detecting changes in neuronal function using pharmacological agents and mouse models.

Main Methods:

  • Utilized manganese-enhanced MRI (MEMRI) to measure manganese ion (Mn(2+)) movement.
  • Administered pharmacological agents (isoflurane, memantine) to modulate neuronal activity.
  • Examined MTI values in knockout mouse models with altered brain function and neurodegeneration.

Main Results:

  • Isoflurane and memantine treatments decreased the MTI value, indicating reduced synaptic transmission or uptake.
  • MTI values showed varied changes (decreases or increases) in knockout mice, correlating with functional and anatomical brain alterations.
  • Demonstrated the MTI's sensitivity to both pharmacological interventions and genetic modifications affecting neuronal function.

Conclusions:

  • The manganese transfer index (MTI) is a viable in vivo metric for assessing transneuronal transport and overall neuronal function.
  • MTI changes effectively reflect alterations in neuronal physiology caused by pharmacological agents and genetic models of brain dysfunction.
  • This approach holds promise for detecting neuronal function changes in animal models relevant to human neurological diseases.