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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

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Related Experiment Videos

Hepatobiliary tuberculosis in western India.

Deepak N Amarapurkar1, Nikhil D Patel, Anjali D Amarapurkar

  • 1Department of Gastroenterology, Bombay Hospital and Medical Research Centre, India.

Indian Journal of Pathology & Microbiology
|July 8, 2008
PubMed
Summary

Localized hepatobiliary tuberculosis (HBTB) is uncommon but diagnosed in 15.7% of TB patients. Early diagnosis using imaging, histology, and microbiology leads to effective treatment with anti-tuberculosis therapy.

Related Experiment Videos

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Tuberculous involvement of the liver is common in disseminated tuberculosis (50-80% of cases).
  • Localized hepatobiliary tuberculosis (HBTB) is infrequently described.
  • This study focuses on the diagnosis and classification of HBTB in patients without miliary TB or immunosuppression.

Purpose of the Study:

  • To prospectively evaluate the prevalence and etiology of liver involvement in tuberculosis (TB) patients.
  • To characterize the clinical, biochemical, and imaging findings of hepatobiliary tuberculosis (HBTB).
  • To classify HBTB cases and assess treatment response.

Main Methods:

  • Prospective evaluation of 280 consecutive TB patients over 6 years.
  • Exclusion of patients with miliary TB, immunosuppression, or prior anti-TB treatment.
  • Diagnosis of HBTB based on imaging, histology (caseating granuloma), acid-fast bacilli smear/culture, and PCR for Mycobacterium tuberculosis.

Main Results:

  • Hepatobiliary tuberculosis (HBTB) was diagnosed in 38 patients (15.7%) among 242 included cases.
  • HBTB cases were classified into hepatic TB (52.6%), biliary TB (39.4%), and mixed variety (7.8%).
  • Hepatic TB included granulomatous hepatitis and liver abscesses/pseudotumors; biliary TB involved strictures, gallbladder, or lymph node obstruction.

Conclusions:

  • Hepatobiliary tuberculosis (HBTB) is an important subgroup within TB cases.
  • A combination of imaging, histological, and microbiological procedures is crucial for diagnosing HBTB.
  • All HBTB cases responded well to standard anti-tuberculosis therapy, highlighting treatment efficacy.