Related Experiment Video

Updated: Jul 3, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

Coronary artery dilation after Kawasaki disease for children within the normal range

Matthew A Crystal1, Cedric Manlhiot, Rae S M Yeung

  • 1Division of Cardiology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada.

International Journal of Cardiology
|July 16, 2008
PubMed

Insights

Longitudinal assessment of coronary artery dimensions in Kawasaki disease (KD) reveals subtle abnormalities. Normalized measurements identify more patients with dilation than standard criteria, highlighting the need for ongoing monitoring post-illness.

Area of Science:

  • Pediatric Cardiology
  • Vascular Biology
  • Rheumatology

Background:

  • Kawasaki disease (KD) is an acute vasculitis with potential coronary artery complications.
  • Coronary artery abnormalities range from dilation to aneurysm formation.
  • Understanding trends in coronary artery dimensions is crucial for managing KD patients.

Purpose of the Study:

  • To determine trends in normalized coronary artery dimensions over time in acute Kawasaki disease.
  • To identify factors associated with normalized coronary artery dimensions.
  • To compare standard criteria with normalized measurements for detecting abnormalities.

Main Methods:

  • Review of clinical data and echocardiograms from 176 patients over 3 years.
  • Coronary artery measurements normalized for body surface area.
  • Mixed linear regression analysis for repeated measures to assess time trends.

Main Results:

  • Standard Japanese criteria identified 11% with abnormalities, while normalized Z-scores > +2 identified 23%.
  • Normalized measurements revealed previously unrecognized dilation in over 50% of patients with initially normal Z-scores.
  • Z-scores decreased logarithmically, primarily within the first 2-3 months post-diagnosis.

Conclusions:

  • Longitudinal assessment of normalized coronary artery measurements is valuable.
  • This approach can identify subtle coronary artery abnormalities missed by standard criteria.
  • Ongoing monitoring may improve outcomes for Kawasaki disease patients.
Abstract

More Related Videos

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...