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Related Experiment Videos

PET and SPECT.

Uwe Haberkorn1

  • 1Department of Nuclear Medicine, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. uwe_haberkorn@med.uni-heidelberg.de

Handbook of Experimental Pharmacology
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

Radionuclide imaging, including SPECT and PET, assesses gene function and regulation. These nuclear medicine techniques visualize gene expression and protein interactions for novel diagnostics and therapeutics.

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Area of Science:

  • Molecular Biology
  • Nuclear Medicine
  • Biochemistry

Background:

  • Human genome sequencing necessitates methods to assess gene function.
  • Genetically modified organisms and novel biomolecules require physiological and biochemical understanding.
  • Radionuclide imaging offers a powerful tool for in-vivo gene function assessment.

Purpose of the Study:

  • To explore the application of radionuclide imaging for gene function assessment.
  • To investigate the use of in-vivo reporter genes and radiolabeled molecules.
  • To highlight the potential for new diagnostic and therapeutic strategies.

Main Methods:

  • Utilizing single-photon emission computed tomography (SPECT) and positron emission tomography (PET) for in-vivo imaging.
  • Employing in-vivo reporter genes (e.g., enzymes, receptors) and radiolabeled substrates, antibodies, or ligands.

Related Experiment Videos

  • Investigating radiolabeled antisense molecules for mRNA analysis and therapeutic oligonucleotides.

    • Main Results:

    • Radionuclide imaging can visualize in-vivo reporter gene expression and protein-protein interactions.
    • Combinations of promoters and reporter genes reveal gene regulation.
    • Potential for noninvasive visualization of signal transduction pathways.
    • Therapeutic applications include targeted DNA breaks and gene therapy for tumors.

    Conclusions:

    • Nuclear medicine procedures are vital for understanding gene function and regulation post-genome sequencing.
    • In-vivo reporter gene imaging enables noninvasive assessment of gene expression and biological processes.
    • These advancements pave the way for innovative diagnostic and therapeutic applications, including targeted cancer therapies.