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Updated: Jul 3, 2026
05:25
Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
[The pathophysiology underlying overactive bladder syndrome possibly due to benign prostatic hyperplasia].
Hironobu Akino1, Masanobu Maegawa, Keiko Nagase
1Department of Urology, University of Fukui.
Hinyokika Kiyo. Acta Urologica Japonica
|July 19, 2008
Summary
Overactive bladder (OAB) in men over 50 with benign prostatic hyperplasia (BPH) involves complex aging, bladder outlet obstruction, and prostate enlargement mechanisms. Understanding these pathways is key to effective treatment strategies.
Area of Science:
- Urology
- Neuroscience
- Gerontology
Context:
- Overactive bladder syndrome (OAB) pathophysiology in men with benign prostatic hyperplasia (BPH) remains unclear.
- Lower urinary tract symptoms (LUTS) are common in men over 50.
- Urgency in LUTS correlates with aging, bladder outlet obstruction (BOO), and benign prostatic enlargement (BPE).
Purpose:
- To investigate the underlying mechanisms of OAB development in the context of BPH.
- To elucidate the roles of aging, BOO, and BPE in OAB pathophysiology.
Summary:
- Aging impairs central nervous system acetylcholine neurons, reducing bladder capacity.
- Non-voiding bladder contractions may contribute to OAB in BOO.
- Urethral C-fibers might be involved in detrusor overactivity associated with BPE.
Impact:
- Reveals the complex pathophysiology of OAB related to BPH.
- Highlights the need for a multidisciplinary approach to treat OAB in BPH patients.
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