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Imaging of the vasa vasorum.

Juan F Granada¹, Steven B Feinstein

¹Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, New York, NY, USA.

Nature Clinical Practice. Cardiovascular Medicine

|July 25, 2008

Summary

Ultrasound imaging can detect new blood vessel growth in artery walls, aiding atherosclerosis diagnosis. This technology, using contrast agents, shows promise for early detection and treatment of cardiovascular disease.

Area of Science:

Cardiovascular Imaging
Vascular Biology
Medical Ultrasound

Background:

Adventitial vasa vasorum neovascularization contributes to atherosclerosis progression and plaque instability.
Intraplaque neovessel formation is linked to complex atheromatous lesion development.
Current understanding of plaque instability mechanisms requires further investigation.

Purpose of the Study:

To explore ultrasound-based techniques for detecting intraplaque neovascularization.
To assess the feasibility of characterizing adventitial neovascularization using imaging.
To highlight the potential of these techniques for early atherosclerosis diagnosis.

Main Methods:

Utilizing ultrasound-based techniques for real-time detection of neovascularization.

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Employing contrast microspheres as acoustic tracers for microvascular enhancement.

Developing and validating imaging techniques in animal models and vascular territories.

Main Results:

Preliminary studies demonstrate technical feasibility of detecting adventitial neovascularization.
Contrast microspheres act as effective intravascular tracers for neovessel quantification.
Ultrasound techniques are under development for carotid and coronary applications.

Conclusions:

Ultrasound-based detection of adventitial vasa vasorum is feasible.
Emerging imaging techniques may enable early diagnosis and risk stratification of atherosclerosis.
Future innovations in contrast agents will enhance diagnostic and therapeutic capabilities.