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Related Experiment Videos

Remote cortical dysfunction in aphasic stroke patients.

G Demeurisse1, M Verhas, A Capon

  • 1Service de Revalidation Neurologique, Hôpital Universitaire Brugmann, Brussels, Belgium.

Stroke
|August 1, 1991
PubMed
Summary
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Stroke patients with left hemisphere lesions show reduced blood flow in the brain. Some patients exhibited blood flow increases in other areas, suggesting functional reorganization may impact language recovery after stroke.

Area of Science:

  • Neuroscience
  • Neurology
  • Stroke Research

Background:

  • Left hemispheric lesions are common after stroke and can lead to aphasia, a language disorder.
  • Understanding the impact of these lesions on cerebral blood flow is crucial for diagnosing and treating language deficits.

Purpose of the Study:

  • To investigate the effects of deep-seated left hemispheric lesions on regional cortical blood flow in aphasic stroke patients.
  • To compare cerebral blood flow patterns at rest and during a functional naming task between stroke patients and healthy controls.
  • To explore the relationship between cerebral blood flow changes, cortical reorganization, and language disorders.

Main Methods:

  • Studied 18 right-handed aphasic stroke patients and 10 healthy controls.
  • Measured regional cerebral blood flow (rCBF) using the two-dimensional xenon-133 inhalation method.

Related Experiment Videos

  • rCBF was assessed both at rest and during a functional naming test.

    • Main Results:

    • Patients exhibited hypoperfusion in the left frontoparietal region at rest compared to controls.
    • Controls showed typical activation patterns in left hemisphere areas during the naming task.
    • Aphasic patients demonstrated a lack of expected blood flow changes in hypoperfused areas and showed increased blood flow in other brain regions bilaterally, particularly those with milder language impairments.

    Conclusions:

    • Deep-seated left hemispheric lesions lead to regional cortical hypoperfusion.
    • Cortical functional reorganization, involving increased blood flow in alternative brain regions, may occur in stroke patients.
    • Remote cortical dysfunction and adaptive changes in blood flow patterns could be significant in the pathophysiology of post-stroke language disorders.