Age accounts for racial differences in ischemic stroke volume in a population-based study
Tarek Zakaria1, Christopher J Lindsell, Dawn Kleindorfer
1Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267-0525, USA.
Cerebrovascular Diseases (Basel, Switzerland)
|August 30, 2008
Summary
Stroke volume in ischemic stroke patients did not differ by race when age was considered. This finding suggests small stroke lesion size may explain the low use of tissue-type plasminogen activator therapy.
Area of Science:
- Neurology
- Stroke Research
- Epidemiology
Background:
- Previous research indicated smaller stroke volumes in Black ischemic stroke patients.
- The Greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS) aimed to compare stroke volumes between racial groups within the same population.
Purpose of the Study:
- To determine if stroke volume differs between Black and White ischemic stroke patients.
- To investigate the influence of age and sex on stroke volume in different racial groups.
Main Methods:
- Phase II of the GCNKSS analyzed ischemic strokes from July 1993 to June 1994.
- Stroke volume was estimated using the modified ellipsoid method by study physicians.
- Analysis included 334 patients (191 White, 143 Black) with measurable lesions (>or=0.5 cm³), stratified by age and sex.
Main Results:
- The median stroke volume for all patients was 8.8 cm³ (mean 36.4 cm³).
- Stroke volume did not differ between sexes but increased with age.
- While initially higher in White patients, this difference disappeared when accounting for age, showing no racial disparity in stroke volume across age groups.
Conclusions:
- Most ischemic stroke lesions are small, irrespective of race.
- Small lesion size may contribute to the limited use of tissue-type plasminogen activator for stroke treatment.
- Further research is needed on the relationship between age and stroke volume.
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