[Role of mitogen-activated protein kinase pathway in chloracne]
Chun-mei Zhang1, Nai-jun Tang, Li Dong
1Department of Occupational Health, School of PublicHealth, Tianjin Medical University, Tianjin 300070, China.
Objective:
To investigate the role of mitogen-activated protein kinase (MAPK) signal transduction pathway in chloracne.
Methods:
Immunohistochemical technique was used to detect the expression of phosphorylated epidermal growth factor receptor (p-EGFR) and p-MAPK proteins in the epithelium of chloracne group and control group.
Results:
p-EGFR and p-MAPK was found in all chloracne tissues, whereas no expression of p-EGFR and p-MAPK protein was found in control group. In the skin of chloracne patients, p-EGFR was mainly distributed in the membrane and the cytoplasm, especially in the vicinity of membrane; major positive signal of p-MAPK was in core and serosity.
Conclusion:
EGFR and MAPK phosphorylation is found in chloracne tissues. MAPK signal transduction pathway is one important molecular mechanism of chloracne.
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