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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Published on: April 3, 2014

Nucleoside diphosphate prodrugs

C Meier1, H J Jessen, J Balzarini

  • 1Organic Chemistry, Department of Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany. chris.meier@chemie.uni-hamburg.de

Nucleic Acids Symposium Series (2004)
|September 9, 2008
PubMed
Summary

Researchers developed novel prodrugs for antiviral therapies, bypassing the need for kinase activation. These bis-(acyloxybenzyl)-masked nucleoside diphosphates (BAB-NDPs) offer controlled release of active drugs like AZT and d4T.

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