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Targeting specific gene by alkylating pyrrole-imidazole polyamides

Masafumi Minoshima1, James Chou, Sophie Lefebvre

  • 1Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, 606-8502, Japan.

Nucleic Acids Symposium Series (2004)
|September 9, 2008
PubMed
Summary

Researchers developed novel small molecules that target specific DNA sequences. These pyrrole-imidazole polyamide seco-CBI conjugates effectively alkylate the histone H4c gene, inhibiting its expression for potential cancer chemotherapy.

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