[Laudation for Reinhard Rüchel]

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...

Gustav Kirchhoff (1824–1887) devised two rules known as Kirchhoff's rules to analyze complex circuits, which cannot be analyzed with series-parallel techniques. These rules can be used to analyze any circuit, simple or complex.
Kirchhoff's first rule is called the junction rule. A junction, also known as a node, is a connection of three or more wires. The rule states that the sum of all currents entering a junction must equal the sum of all currents leaving the junction.

Kirchhoff's rules quantify the current flowing through a circuit and the voltage variations around the loop in a circuit. Applying Kirchhoff's rules generates a set of linear equations that allow us to find the unknown values in circuits. These may be currents, voltages, or resistances.
When applying Kirchhoff's first rule, the junction rule, label the current in each branch and decide its direction. If the chosen direction is wrong, it will have the correct magnitude, although the current will...

To determine the electron configuration for any particular atom, we can build the structures in the order of atomic numbers. Beginning with hydrogen, and continuing across the periods of the periodic table, we add one proton at a time to the nucleus and one electron to the proper subshell until we have described the electron configurations of all the elements. This procedure is called the aufbau principle, from the German word aufbau (“to build up”). Each added electron occupies the subshell of...