Related Experiment Video
Updated: Jul 1, 2026
10:45
Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
Published on: June 13, 2018
[Linear ulcers with central keratinous plug].
R Rüger1, R Treudler, U Paasch
1Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig A.ö.R., Philipp-Rosenthal-Strasse 23-25, 04103, Leipzig. robin.rueger@medizin.uni-leipzig.de
Summary
Reactive perforating dermatosis (RPD) is a rare skin condition. This case study shows promising results using allopurinol, an effective treatment option for RPD.
Area of Science:
- Dermatology
- Histopathology
Background:
- Reactive perforating dermatosis (RPD) is a primary perforating dermatosis.
- Histological features include transepidermal discharge of basophilic material and vertically arranged collagen fibers.
Observation:
- Standard treatments for RPD include keratolytic agents, glucocorticosteroids, retinoids, antihistamines, and photochemotherapy.
- A patient with RPD presented for case study.
Findings:
- The patient demonstrated a significant positive response to allopurinol treatment.
- Allopurinol emerged as a highly effective therapeutic option in this case.
Implications:
- Allopurinol represents a potential novel therapeutic strategy for managing reactive perforating dermatosis.
- Further research into allopurinol for RPD treatment is warranted.
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