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Updated: Jun 30, 2026
08:58
Fluorimetric Techniques for the Assessment of Sperm Membranes
Published on: November 28, 2018
[Why and how to assess hypospermia?].
G Robin1, F Marcelli, V Mitchell
1Service d'andrologie, hôpital Albert-Calmette, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France. geoffroy.robin@laposte.net
Gynecologie, Obstetrique & Fertilite
|September 20, 2008
Summary
Hypospermia, a low semen volume, can stem from ejaculation issues or anatomical problems. Cystic fibrosis gene mutations are a potential cause, making genetic screening crucial for patients and their descendants.
Area of Science:
- Reproductive Medicine
- Medical Genetics
Context:
- Hypospermia is defined as semen volume < 2 mL.
- Etiologies include ejaculation reflex disturbances and seminal tract anomalies.
Purpose:
- To explore the link between CFTR gene mutations and hypospermia.
- To highlight the importance of genetic screening for CFTR mutations in hypospermia cases.
Summary:
- Hypospermia can result from partial retrograde ejaculation or seminal gland/duct anomalies.
- Mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene are identified as a potential cause.
- Molecular screening of the CFTR gene is vital for reproductive and patient health.
Impact:
- Informs clinical practice regarding the investigation of hypospermia.
- Emphasizes the significance of genetic counseling and testing for hereditary conditions.
- Contributes to understanding the genetic basis of male infertility.
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