Related Experiment Video
Updated: Jun 30, 2026
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Reversible pH lability of cross-linked vault nanocapsules
Marcella Yu1, Benny C Ng, Leonard H Rome
1Chemical and Biomolecular Engineering Department, University of California, Los Angeles, Los Angeles, California 90095, USA.
None:
Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10,000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.
