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Updated: Jun 30, 2026

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 15, 2024
[Residual limb pain from bone overgrowth after amputation]
Niels Risum1, Anne Grønbaek, Jørgen Jesper Hvolris
1Gasvaerksvej 4B, 2., DK-1656 København V. nielsrisum@hotmail.com
Bone overgrowth, or ossification, can complicate amputations, causing residual limb pain. This rare condition requires consideration as a differential diagnosis in amputees experiencing pain.
Area of Science:
- Orthopedics
- Surgical Complications
- Regenerative Medicine
Background:
- Bone overgrowth is classified as heterotopic or orthotopic ossification.
- Residual limb pain is a common complication following amputation.
- Literature on bone overgrowth after amputation is scarce.
Observation:
- Three adult amputees presented with complications due to bone overgrowth.
- These cases highlight bone overgrowth as a differential diagnosis for residual limb pain.
- Heterotopic ossification following non-traumatic amputation complications is not previously reported.
Findings:
- Bone overgrowth can lead to significant complications in amputees.
- It presents a crucial differential diagnosis for residual limb pain.
- This study reports heterotopic ossification in non-traumatic amputation complications.
Implications:
- Clinicians should consider bone overgrowth in amputees with unexplained residual limb pain.
- Further research is needed to understand the mechanisms and incidence of bone overgrowth post-amputation.
- Improved diagnostic and management strategies for bone overgrowth in amputees may be warranted.
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