Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis

Area of Science:

• Ophthalmology
• Corneal Diseases
• Ocular Surface Disease

Background:

• Superior limbic keratoconjunctivitis (SLK) is a chronic inflammatory condition affecting the ocular surface.
• Current treatments for SLK can be limited in efficacy and may have side effects.

Purpose of the Study:

• To evaluate the efficacy of liquid nitrogen cryotherapy as a treatment for superior limbic keratoconjunctivitis (SLK).

Main Methods:

• An interventional case series was conducted involving patients diagnosed with SLK.
• Liquid nitrogen cryotherapy was applied using a standardized technique with a double freeze-thaw cycle.
• Outcomes were assessed based on the resolution of SLK signs and symptoms.

Main Results:

• Seven eyes across four female patients with SLK were treated with liquid nitrogen cryotherapy.
• Complete resolution of SLK was observed within two weeks for all treated patients.
• Recurrence occurred in two patients (three of seven eyes), but repeat cryotherapy successfully eradicated the disease in all cases.
• No adverse ocular events were reported during the study.

Conclusions:

• Liquid nitrogen cryotherapy is a safe and effective treatment option for superior limbic keratoconjunctivitis.
• Long-term cures were achieved in all patients, with repeat cryotherapy being a viable option if needed.
• Repeat cryotherapy, if necessary, can be performed approximately three months after the initial treatment.