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Updated: Jun 29, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Long bone florid reactive periostitis ossificans: a case in the distal femur mimicking osteosarcoma
Daniel Azorín1, Miguel A López-Pino, Imelda González-Mediero
1Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. dazorin.hnjs@salud.madrid.org
Abstract:
Florid reactive periostitis ossificans is a well-known benign lesion classically described in hands and feet which histopathological features can lead to a misdiagnosis of osteosarcoma. To the best of our knowledge, there is only one previous report of this lesion in a long bone. In this study we report a case of florid reactive periostitis ossificans located in the distal metaphysis of the left femur that histologically mimicked an osteosarcoma and discuss the differential diagnosis between these two entities to warn about a diagnostic pitfall.
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