Related Experiment Video
Updated: Jun 29, 2026
07:00
A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
Published on: August 14, 2013
Hypertension and the eye.
John T DellaCroce1, Albert T Vitale
1John A Moran Eye Center, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
Current Opinion in Ophthalmology
|October 16, 2008
Summary
Hypertension causes eye changes like retinopathy and optic neuropathy. Routine eye exams can predict cardiovascular risk and aid in managing hypertension complications.
Area of Science:
- Ophthalmology
- Cardiology
- Vascular Biology
Background:
- Systemic hypertension leads to observable changes in retinal microvasculature.
- These ocular changes include retinopathy, choroidopathy, and optic neuropathy.
- Hypertension increases the risk of various ocular vascular abnormalities and conditions like diabetic retinopathy, glaucoma, and age-related macular degeneration.
Purpose of the Study:
- To review the ocular manifestations of systemic hypertension.
- To explore the predictive value of fundoscopic findings for overall health.
- To discuss the correlation between ocular hypertensive changes and systemic vascular disease severity.
Main Methods:
- Review of current literature on hypertension and ocular findings.
- Analysis of revised grading systems for hypertensive retinopathy.
- Discussion of the role of digital imaging and computer analysis in fundoscopic examination.
Main Results:
- Digital imaging and revised grading systems enhance the precision of fundoscopic examinations.
- Fundoscopic screening can identify microvascular changes indicative of cardiovascular risk.
- Ocular findings can provide prognostic information for disease progression.
Conclusions:
- Routine fundoscopic screening for hypertensive patients is valuable.
- Early detection of microvascular changes aids in prevention and management.
- Ocular examination is a key modality for managing both ocular and systemic complications of hypertension.
Related Concept Videos
01:18Hypertension and Regulation of Blood Pressure
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
01:28Hypertension I: Introduction
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
01:30Alterations in Blood Pressure
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
01:29Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...