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Updated: Jun 28, 2026
14:28
Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Human immunodeficiency virus type 1, human protein interaction database at NCBI.
William Fu1, Brigitte E Sanders-Beer, Kenneth S Katz
1Southern Research Institute, Frederick, MD 21701, USA. fu@southernresearch.org
Nucleic Acids Research
|October 18, 2008
Summary
The Human Immunodeficiency Virus Type 1 (HIV-1) Protein Interaction Database catalogs HIV-1 and human protein interactions. This resource aids researchers in discovering new HIV vaccine candidates and therapeutic targets.
Area of Science:
- Virology
- Molecular Biology
- Bioinformatics
Background:
- Human Immunodeficiency Virus Type 1 (HIV-1) interactions with human proteins are crucial for understanding viral pathogenesis and replication.
- Identifying these interactions is key for developing novel therapeutic targets and vaccine candidates.
Purpose of the Study:
- To create and maintain a comprehensive database cataloging all published HIV-1 and human protein interactions.
- To provide researchers with easily accessible data to facilitate the discovery of HIV interventions.
Main Methods:
- Systematic curation of peer-reviewed literature to identify HIV-1 human protein interactions.
- Data compilation including RefSeq protein accession numbers, Entrez Gene IDs, interaction descriptions, keywords, and PubMed IDs (PMIDs).
- Integration of interaction data into Entrez Gene records and linkage with other relevant databases.
Main Results:
- The database currently stores 2589 unique HIV-1 to human protein interactions with 5135 descriptions.
- Includes 14,312 PMID references to original research articles.
- All documented protein-protein interactions are integrated into Entrez Gene reports.
Conclusions:
- The HIV-1 Human Protein Interaction Database serves as a valuable, centralized resource for the scientific community.
- Facilitates research into HIV pathogenesis, replication, and the identification of potential therapeutic targets and vaccine strategies.
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