Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The nitrogen starvation-induced inhibitor Rts3 restrains Sit4/PP6 to gate quiescence downstream of TORC1.

Nature communications·2026
Same author

CIMT 2025: Report on the 22<sup>nd</sup> Annual Meeting of the Association for Cancer Immunotherapy.

Human vaccines & immunotherapeutics·2025
Same author

Along the Trajectory to Understanding Cellular Aging: More Lessons from Yeast.

Annual review of cell and developmental biology·2025
Same author

Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy.

Molecular cell·2025
Same author

Retraction Note: A mechanism for the suppression of homologous recombination in G1 cells.

Nature·2025
Same author

Oxidation-sensitive cysteines drive IL-38 amyloid formation.

Cell reports·2024
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Nutrient signals driving cell growth.

Reinhard Dechant1, Matthias Peter

  • 1Competence Center for Systems Physiology and Metabolic Diseases, Zurich, Switzerland. reinhard.dechant@bc.biol.ethz.ch

Current Opinion in Cell Biology
|October 22, 2008
PubMed
Summary
This summary is machine-generated.

Cell growth regulation relies on nutrient sensing pathways like TORC1 and PKA. New research reveals calcium’s role in TORC1 activation and glucose metabolites in PKA activation, advancing understanding of nutrient signaling.

More Related Videos

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
11:01

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids

Published on: September 25, 2016

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells
11:02

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

Published on: August 13, 2021

Related Experiment Videos

Last Updated: Jun 28, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
11:01

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids

Published on: September 25, 2016

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells
11:02

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

Published on: August 13, 2021

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Nutrient sensing is vital for cell survival, with TORC1 and PKA pathways regulating growth in yeast.
  • Mechanisms linking intracellular metabolic signals to TORC1 and PKA activation are not fully understood.
  • The endomembrane system and calcium ions are implicated in nutrient sensing pathways.

Purpose of the Study:

  • To elucidate the molecular mechanisms of nutrient sensing in yeast.
  • To identify key signaling molecules and pathways involved in cell growth regulation.
  • To explore the roles of calcium and glucose metabolites in TORC1 and PKA activation.

Main Methods:

  • Utilized genetic analysis to investigate PKA pathway activation.
  • Employed novel quantitative approaches to study nutrient sensing mechanisms.
  • Reviewed recent studies identifying TORC1 activators and the role of the endomembrane system.

Main Results:

  • Calcium identified as a crucial second messenger for TORC1 activation by amino acids.
  • Genetic analysis revealed intracellular glucose metabolites are key for PKA activation.
  • Identified potential activators of TORC1 and highlighted the endomembrane system's importance.

Conclusions:

  • Findings provide foundational knowledge on nutrient sensing mechanisms in yeast.
  • Understanding these pathways offers insights into human nutrient sensing and metabolic regulation.
  • Further research using quantitative methods will refine our understanding of these essential cellular processes.