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The effect of the different uncertainty models in dose expected volume histogram computation
F Cutanda Henríquez1, S Vargas Castrillón
1Servicio de Medicina Nuclear, Hospital General Universitario Gregorio Marañón, Madrid, Spain. francisco.cutanda@hotmail.com
Dose expected volume histograms (DEVH) offer a robust alternative to standard dose volume histograms by incorporating computational uncertainties in radiation therapy. The study confirms that the standard deviation of point dose computations significantly impacts DEVH, more so than the choice of probability distribution.
Area of Science:
- Radiation Oncology
- Medical Physics
- Computational Dosimetry
Background:
- Dose volume histograms (DVH) are standard for radiation therapy planning but do not account for computational uncertainties.
- Dose expected volume histograms (DEVH) were developed to address this limitation, often assuming a rectangular probability distribution for uncertainties.
- Computational uncertainties in external beam radiation therapy (EBRT) necessitate robust evaluation methods.
Purpose of the Study:
- To investigate the impact of different point dose uncertainty models on dose expected volume histograms.
- To compare the influence of various probability distributions versus the standard deviation of point dose computations on DEVH outcomes.
Main Methods:
- Investigated changes in DEVH using alternative recommended point dose uncertainty models.
- Analyzed the effect of different probability distributions (e.g., rectangular) on DEVH.
- Evaluated the sensitivity of DEVH to the standard uncertainty of point dose computations.
Main Results:
- The choice of probability distribution among recommended models has a minimal effect on DEVH.
- The standard uncertainty of point dose computations is the primary factor influencing DEVH.
- DEVH provide a more comprehensive assessment of dose distribution under uncertainty.
Conclusions:
- DEVH are a valuable tool for accounting for computational uncertainties in radiation therapy.
- The standard deviation of point dose is the critical parameter for DEVH, simplifying uncertainty analysis.
- Clinical adoption of DEVH can improve the reliability of radiation therapy planning and reporting.
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