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Related Experiment Video

Updated: Jun 28, 2026

Next-generation Sequencing of 16S Ribosomal RNA Gene Amplicons

Next-generation Sequencing of 16S Ribosomal RNA Gene Amplicons

Published on: August 29, 2014

A new grading of Pierre Robin sequence.

Annie Cole¹, Patricia Lynch, Rona Slator

¹West Midlands Regional Cleft Lip and Palate Service, Birmingham Children's Hospital, West Midlands, United Kingdom.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association

|October 30, 2008

Summary

A new grading system for Pierre Robin sequence (PRS) clarifies care for neonates with airway obstruction and feeding issues. This classification improves communication among healthcare professionals caring for infants with PRS.

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Area of Science:

Medical Science
Pediatric Care
Neonatology

Background:

Pierre Robin sequence (PRS) is characterized by micrognathia, glossoptosis, and cleft palate.
Neonates with PRS experience variable airway obstruction and feeding difficulties, leading to inconsistent definitions and management.
Historical classification at Birmingham Children's Hospital identified only severe cases as "true" PRS, excluding milder presentations.

Purpose of the Study:

To devise and describe a new system for classifying babies with Pierre Robin sequence (PRS).
The classification aims to standardize the grading of PRS based on symptom severity and required treatment.
To address inconsistencies in PRS diagnosis and management.

Main Methods:

Development of a novel classification system for Pierre Robin sequence (PRS).
Categorization of PRS cases into three distinct grades based on clinical presentation and management needs.
Implementation of the new grading system within a clinical setting.

Main Results:

The implemented three-grade classification system for Pierre Robin sequence (PRS) has successfully clarified care pathways.
Enhanced communication has been observed between Cleft Clinical Nurse Specialists and other healthcare professionals.
Standardized grading has improved the consistency of care for neonates with PRS.

Conclusions:

The new PRS classification provides a clear framework for managing affected neonates.
Improved communication and standardized care pathways result from the adopted grading system.
This approach facilitates better data comparison and clinical collaboration in Pierre Robin sequence management.