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Related Concept Videos

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

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Related Experiment Video

Updated: Jun 28, 2026

Evaluating the Effect of Environmental Chemicals on Honey Bee Development from the Individual to Colony Level
07:39

Evaluating the Effect of Environmental Chemicals on Honey Bee Development from the Individual to Colony Level

Published on: April 1, 2017

Changes in protein expression during honey bee larval development.

Queenie W T Chan1, Leonard J Foster

  • 1Centre for High-Throughput Biology, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada. queeniecwt@shaw.ca

Genome Biology
|October 31, 2008
PubMed
Summary
This summary is machine-generated.

Honey bee larvae show increased protein transporters and nutrient stores with age, but decreased translation and antioxidants. This developmental proteomics study reveals insights into honey bee immunity and metabolism.

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Preparation of Single-cohort Colonies and Hormone Treatment of Worker Honeybees to Analyze Physiology Associated with Role and/or Endocrine System
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Measuring Hypopharyngeal Gland Acinus Size in Honey Bee (Apis mellifera) Workers
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Last Updated: Jun 28, 2026

Evaluating the Effect of Environmental Chemicals on Honey Bee Development from the Individual to Colony Level
07:39

Evaluating the Effect of Environmental Chemicals on Honey Bee Development from the Individual to Colony Level

Published on: April 1, 2017

Preparation of Single-cohort Colonies and Hormone Treatment of Worker Honeybees to Analyze Physiology Associated with Role and/or Endocrine System
08:53

Preparation of Single-cohort Colonies and Hormone Treatment of Worker Honeybees to Analyze Physiology Associated with Role and/or Endocrine System

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Measuring Hypopharyngeal Gland Acinus Size in Honey Bee (Apis mellifera) Workers
05:11

Measuring Hypopharyngeal Gland Acinus Size in Honey Bee (Apis mellifera) Workers

Published on: September 14, 2018

Area of Science:

  • Proteomics
  • Developmental Biology
  • Insect Biochemistry

Background:

  • Honey bees (Apis mellifera) are vital pollinators and a model organism for social organism development, metabolism, and immunity.
  • Larval development is a critical stage influencing adult bee health and colony success.

Purpose of the Study:

  • To quantify protein expression profiles during honey bee larval development (5-6 days).
  • To understand age-correlated changes in protein metabolism, nutrient storage, and immune factor levels.

Main Methods:

  • Mass spectrometry-based quantitative proteomics.
  • Analysis of approximately 800 proteins during honey bee larval stages.

Main Results:

  • Age-correlated increase in protein transporters, receptors, and nutrient stores.
  • Decreased protein translation activity and turnover with larval aging.
  • Differential regulation of immune factors; prophenoloxidase and apismin increase, while some others do not, potentially explaining disease susceptibility.
  • Reduction in antioxidant and G proteins in aging larvae.

Conclusions:

  • Integrated model of larval metabolism and immune system maturation in honey bees.
  • Protein expression data provide a resource for generating new hypotheses in honey bee research.
  • Findings may explain age-associated susceptibility to bacterial (e.g., American Foulbrood) and fungal (e.g., chalkbrood) diseases.