Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence over 21 Years of Follow-up in the Diabetes Prevention Program.

Cancer prevention research (Philadelphia, Pa.)·2025
Same author

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium.

Genome medicine·2025
Same author

Developing a Computable Phenotype for Identifying Children, Adolescents, and Young Adults With Diabetes Using Electronic Health Records in the DiCAYA Network.

Diabetes care·2025
Same author

Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts.

Environment international·2025
Same author

Neurobehavioral effects of gestational exposure to mixtures of non-persistent endocrine disruptors in preschool-aged children: The environmental influences on child health outcomes (ECHO) program.

Environmental research·2025
Same author

Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort.

Journal of exposure science & environmental epidemiology·2025
Same journal

Sex Hormones & Exercise in the Musculoskeletal System: From Signaling to Structure and Function.

Endocrine reviews·2026
Same journal

DAX-1 in sex determination and gonadal development: revisiting the anti-testis hypothesis.

Endocrine reviews·2026
Same journal

Regulators of Appetite in Mammals - Old and New players.

Endocrine reviews·2026
Same journal

Endometriosis-associated Pain: Mechanism, Neuroimmune Signature, and Translational Precision Strategies.

Endocrine reviews·2026
Same journal

Nuclear Receptors Shape Sepsis Pathophysiology.

Endocrine reviews·2026
Same journal

Beyond aldosterone and renin: emerging biomarkers for diagnosing and subtyping primary aldosteronism.

Endocrine reviews·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

The metabolic syndrome.

Marc-Andre Cornier1, Dana Dabelea, Teri L Hernandez

  • 1University of Colorado Denver, Division of Endocrinology, Metabolism, and Diabetes, Mail Stop 8106, 12801 East 17 Avenue, Room 7103, Aurora, Colorado 80045, USA. marc.cornier@ucdenver.edu

Endocrine Reviews
|October 31, 2008
PubMed
Summary
This summary is machine-generated.

Metabolic syndrome (MetS) is a growing health issue linked to obesity and inactivity. Lifestyle changes and weight loss are key to managing MetS and reducing risks of heart disease and type 2 diabetes.

More Related Videos

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Related Experiment Videos

Last Updated: Jun 28, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Public Health

Background:

  • Metabolic syndrome (MetS) is a cluster of conditions including abdominal obesity, insulin resistance, dyslipidemia, and hypertension.
  • It is associated with increased risks of cardiovascular disease, type 2 diabetes, and other comorbidities.
  • The prevalence of MetS is rising globally due to overnutrition and sedentary lifestyles.

Purpose of the Study:

  • To define metabolic syndrome (MetS) and its associated health risks.
  • To highlight the central role of abdominal adiposity and insulin resistance in MetS.
  • To emphasize lifestyle modifications as a primary treatment and prevention strategy.

Main Methods:

  • Review of existing literature and definitions of MetS.
  • Analysis of epidemiological data on MetS prevalence and associated risks.
  • Synthesis of current understanding of MetS pathophysiology.

Main Results:

  • MetS is characterized by a constellation of risk factors, not a single disease entity.
  • Individuals with MetS have a doubled risk of cardiovascular disease and a 5-fold increased risk of type 2 diabetes.
  • Abdominal obesity and insulin resistance are considered central pathophysiological components.

Conclusions:

  • Lifestyle modification and weight loss are fundamental for MetS management and prevention.
  • Aggressive management of other cardiac risk factors is recommended for individuals with MetS.
  • MetS is an evolving concept, continuously updated with new evidence.