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Updated: Jun 28, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
[Study on self-microemulsifying drug delivery system of Jiaotai Pill active components]
Bei-En Zhang1, Wen-Biao Lu, Wei-Wen Chen
1Guangzhou University of TCM, Guangzhou 510006, China. beien_83@yahoo.com.cn
Objective:
To develop self-microemulsifying drug delivery system (SMEDDS) of Jiaotai Pill active components and its quality control method.
Methods:
The solubility of berberine hydrochloride in different auxiliary-materials were investigated, and the self-microemulsion formula was optimized by studying the self-microemulsifying efficiency. The content of berberine hydrochloride and cinnamaldehyde in the preparation were determined by HPLC.
Results:
The optimal self-microemulsion formula was composed of OP, propanediol, cinnamon oil, and total alkaloid from Rhizoma Coptidis with the ratio of 4:8:3:6. The average size of the microemulsion particle was 15.8 nm; the average content of berberine hydrochloride and cinnamaldehyde in the preparation was above 20.0% and 10.0%, respectively.
Conclusion:
The acquired microemulsion with small particle size is stable. The determination method of berberine hydrochloride and cinnamaldehyde in the preparation is accurate and reliable.
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