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Updated: Jun 28, 2026
Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
Published on: July 28, 2023
Temporal proteomic analysis of intestine developing necrotizing enterocolitis following enteral formula feeding to
Pingping Hang1, Per T Sangild, Wai-Hung Sit
1Division of Agricultural, Food and Nutritional Science, School of Biological Sciences, The University of Hong Kong, China.
Abstract:
Necrotizing enterocolitis (NEC), a serious gastrointestinal inflammatory disease, frequently occurs in preterm neonates that fail to adapt to enteral nutrition. A temporal gel-based proteomics study was performed on porcine intestine with NEC lesions induced by enteral formula feeding. Functional assignment of the differentially expressed proteins revealed that important cellular functions, such as the heat shock response, protein processing; and purine, nitrogen, energy metabolism, were possible involved in the early progression of NEC.
