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Antiviral Nucleoside Inhibitors01:22

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Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
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Nucleic acids02:43

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Nucleic Acids02:43

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Updated: Jun 28, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Nucleic acids as therapeutic agents.

Luis M Alvarez-Salas1

  • 1Laboratorio de Terapia Génica, Departamento de Genética y Biología Molecular, CINVESTAV, México DF 07360, México. lalvarez@cinvestav.mx

Current Topics in Medicinal Chemistry
|November 11, 2008
PubMed
Summary
This summary is machine-generated.

Therapeutic nucleic acids (TNAs) show promise for treating cancer and viral infections. While facing challenges like delivery and side effects, therapeutic oligonucleotides are advancing as a versatile treatment option.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Therapeutic nucleic acids (TNAs) encompass nucleotides, oligonucleotides, and polynucleotides used in treating diseases.
  • TNAs are classified by their therapeutic rationale and mechanism of action.
  • This review focuses on TNAs in clinical trials for anticancer and antiviral applications.

Purpose of the Study:

  • To review the clinical progress of therapeutic nucleic acids (TNAs) in cancer and antiviral therapies.
  • To highlight the successes and challenges of different TNA classes in clinical applications.
  • To assess the future potential of TNAs, particularly oligonucleotides, in treating major diseases.

Main Methods:

  • Literature review of TNAs in clinical trials.
  • Analysis of TNA classifications: nucleotides, oligonucleotides, and polynucleotides.
  • Evaluation of efficacy, delivery, and safety profiles for different TNA types.

Main Results:

  • Nucleotides/nucleosides are effective but cause toxic side effects.
  • Oligonucleotides like antisense oligodeoxynucleotides (AS-ODNs) and aptamers show clinical success, despite delivery and specificity challenges.
  • Small interfering RNAs (siRNAs) and DNA vaccines face significant hurdles in clinical application.

Conclusions:

  • Therapeutic oligonucleotides, particularly AS-ODNs and aptamers, are the most promising TNA class for cancer and viral diseases.
  • Overcoming delivery and specificity issues is crucial for widespread TNA therapeutic use.
  • Continued research in therapeutic oligonucleotides positions them as future treatments of choice.