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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Related Experiment Videos

Pancoast tumors.

Gavin A Davis1, Simon R Knight

  • 1Neurosurgery, Cabrini Medical Centre, Suite 53, Malvern, Victoria 3144, Australia. gadavis@netspace.net.au

Neurosurgery Clinics of North America
|November 18, 2008
PubMed
Summary
This summary is machine-generated.

This study introduces a modified Pancoast tumor treatment protocol involving neurolysis and brachial plexus preservation. This approach improves survival and preserves hand function, challenging the need for brachial plexus resection.

Related Experiment Videos

Area of Science:

  • Thoracic Surgery
  • Neurosurgery
  • Oncology

Background:

  • Pancoast tumors, or superior sulcus tumors, invade the thoracic outlet, often affecting the brachial plexus.
  • Traditional treatment involves resection, leading to functional deficits and pain.
  • Improved survival has been achieved with induction chemoradiotherapy and surgery.

Purpose of the Study:

  • To evaluate a modified treatment protocol for Pancoast tumors.
  • To assess the feasibility and outcomes of preserving the brachial plexus during surgical resection.
  • To determine if brachial plexus resection is necessary for oncologic outcomes.

Main Methods:

  • Patients received induction chemoradiation followed by surgical resection.
  • Thoracic surgeons resected the lung tumor.
  • Neurosurgeons performed neurolysis and preserved the brachial plexus.

Main Results:

  • The modified protocol demonstrated improved survival outcomes.
  • Patients achieving a pathologic complete response showed preserved hand function.
  • This suggests that brachial plexus resection may not be required.

Conclusions:

  • A modified Pancoast tumor treatment protocol involving brachial plexus preservation is effective.
  • This approach can lead to improved survival and functional outcomes.
  • Preserving the brachial plexus is a viable option, potentially avoiding significant morbidity.