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Updated: Jun 27, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Relationship between parameters of lipid peroxidation during obstructive jaundice and after bile flow restoration
L B Dudnik1, A N Tsupko, M A Shupik
1E. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences. ibd@sky.chph.ras.ru
Abstract:
Restoration of bile flow after 9-day cholestasis in rat liver normalized the content of lipid peroxidation products. The removal of the cholestatic factor after 12-day cholestasis was not followed by recovery of these parameters. We showed that measurement of serum concentration of lipid peroxidation products in patients with cholelithiasis during the preoperative period holds promise for selection of the optimum time for surgical treatment and prediction of the risk of postoperative complications.
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