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Related Concept Videos

Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

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Related Experiment Video

Updated: Jun 27, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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Complement factor H: using atomic resolution structure to illuminate disease mechanisms.

Paul N Barlow1, Gregory S Hageman, Susan M Lea

  • 1School of Chemistry and Biological Sciences, Joseph Black Chemistry Building, University of Edinburgh, Edinburgh EH9 2PB, UK. Paul.Barlow@ed.ac.uk

Advances in Experimental Medicine and Biology
|November 26, 2008
PubMed
Summary
This summary is machine-generated.

Variant forms of Complement Factor H are linked to serious diseases. Understanding its structure and function, particularly its interaction with carbohydrates, may reveal new therapeutic strategies for complement-mediated damage.

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Area of Science:

  • Immunology and Molecular Biology
  • Complement System Regulation

Background:

  • Complement Factor H (CFH) is a critical regulator of the complement system.
  • Recent findings link CFH variants to various severe disease states.
  • Understanding CFH's molecular function is key to exploring therapeutic avenues.

Purpose of the Study:

  • To review recent data on the structure and biological activity of Complement Factor H.
  • To explore how molecular insights into CFH function can lead to novel therapeutics.
  • To examine the hypothesis linking CFH sequence variations to disease predisposition via altered carbohydrate recognition.

Main Methods:

  • Literature review of recent data on Complement Factor H structure and function.
  • Analysis of evidence supporting and refuting the carbohydrate-recognition hypothesis.
  • Examination of disease-associated sequence variations in CFH.

Main Results:

  • CFH variants are increasingly implicated in diverse pathological conditions.
  • The ability of CFH to recognize and interact with host surface carbohydrates is crucial for its protective function.
  • Sequence variations may impair this recognition, potentially leading to complement-mediated damage and disease.

Conclusions:

  • A detailed molecular understanding of Complement Factor H function is essential.
  • Targeting CFH structure-function relationships offers potential for novel therapeutic interventions.
  • Further investigation into CFH-carbohydrate interactions is warranted to elucidate disease mechanisms.