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Updated: Jun 27, 2026

Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs
Published on: June 23, 2022
The study of immunological component in antitumor effect of Trypanosoma cruzi
A V Zenina1, E G Kravtsov, B Tsetsegsaikhan
1Department of Microbiology, Russian University of People Friendship.
Abstract:
The experiments with passive transfer of splenocytes obtained from animals immunized with Trypanosoma cruzi lysate revealed the role of cell-mediated component of the immunity in the antitumor effect of T. cruzi. The common features of T. cruzi antigens and tumor-specific antigens of Ehrlich's adenocarcinoma were demonstrated. These antigens were shown to have common epitopes with mammalian mucins. The oncoprotective effect was achieved by immunization with type II and III mucins and was reproduced after passive transfer of splenocytes from immunized animals.
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