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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Real-time processing for Fourier domain optical coherence tomography using a field programmable gate array.

Teoman E Ustun1, Nicusor V Iftimia, R Daniel Ferguson

  • 1Physical Sciences Inc., Andover, Massachusetts 01810I, USA.

The Review of Scientific Instruments
|December 3, 2008
PubMed
Summary
This summary is machine-generated.

We developed a flexible hardware-accelerated system for real-time processing of Fourier domain optical coherence tomography (FDOCT) images, achieving rapid display rates crucial for applications like image-guided surgery.

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Area of Science:

  • Biomedical Imaging
  • Optical Coherence Tomography
  • Real-time Image Processing

Background:

  • Real-time display of processed Fourier domain optical coherence tomography (FDOCT) images is critical for applications requiring immediate visual feedback, such as rapid screening and image-guided surgery.
  • High computational demands of FDOCT image processing often limit display rates, preventing them from matching acquisition rates in many systems.

Purpose of the Study:

  • To design and develop a flexible, in-line image processing system enabling real-time display of processed FDOCT images at rapid line rates.
  • To overcome the limitations of conventional computer processing for high-speed FDOCT imaging.

Main Methods:

  • Developed a hardware-based system utilizing a field-programmable gate array (FPGA), firmware, and software for accelerated FDOCT image processing.
  • Designed the system for in-line integration between FDOCT detectors and Camera Link frame grabbers, with two versions for spectrometer-based and swept source-based FDOCT.
  • Tested the system using adaptive optics retinal imagers (humans, monkeys), a dual-beam Doppler instrument (zebrafish), and a swept source microscope (human tissue).

Main Results:

  • Achieved a display frame rate of 27 frames per second (fps) for fully processed FDOCT images (1024 axial pixels x 512 lateral A-scans) in spectrometer-based systems.
  • Demonstrated system flexibility and effectiveness across various FDOCT applications and biological models.

Conclusions:

  • The developed system successfully enables real-time display of processed FDOCT images, significantly enhancing usability for time-sensitive applications.
  • This hardware-accelerated approach overcomes computational bottlenecks, paving the way for faster and more efficient OCT-based imaging and interventions.