[Effectiveness of intraoperative fluorescence for diagnosis of malignant lymphoma]

Primary central nervous system lymphoma is generally treated with radiochemotherapy, but surgical treatment can be used in combination with biopsy. We used fluorescein Na to provide intraoperative fluorescence during biopsy to improve the safety and accuracy of surgical treatment. After dural incision, fluorescein Na was administered intravenously at 20 mg/kg, which is double the usual dose, and appeared in the tumor after 10 to 15 minutes. Yellow-stained tissue was collected during stereotactic biopsy. Strongly fluorescent tumor cells were observed under the microscope; these cells would have otherwise been difficult to distinguish from normal brain tissue. Sufficient fluorescence was observed endoscopically, and we conclude that use of fluorescein Na is effective in diagnosis and surgery for malignant lymphoma.