Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
Capillary Beds01:20

Capillary Beds

Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
Capillaries connect arterioles, small branches of arteries, to venules,...
Microenvironments01:22

Microenvironments

Microorganisms inhabit highly localized spaces known as microenvironments, which are defined by distinct physical and chemical characteristics. These include oxygen concentration, pH, temperature, light availability, and nutrient levels. The conditions within a microenvironment can differ markedly from those in the surrounding area and significantly influence microbial growth, metabolism, and community structure.Microenvironments often display sharp physicochemical gradients over small spatial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intra-cardiac transfer of fatty acids from capillary to cardiomyocyte.

PloS one·2022
Same author

Semi-automated Modular Program Constructor for physiological modeling: Building cell and organ models.

F1000Research·2017
Same author

Equations for O<sub>2</sub> and CO<sub>2</sub> solubilities in saline and plasma: combining temperature and density dependences.

Journal of applied physiology (Bethesda, Md. : 1985)·2017
Same author

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance.

Interface focus·2016
Same author

The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen.

Advances in experimental medicine and biology·2016
Same author

Modeling Fatty Acid Transfer from Artery to Cardiomyocyte.

PLoS computational biology·2015
Same journal

Carbon Dioxide Concentration Alters the Dynamics of Oxygen-Mediated Capillary Blood Flow Responses in Skeletal Muscle.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

Diabetes Upregulates BK<sub>Ca</sub> Channels in Pulmonary Arterial Smooth Muscle by Altering the Local Control Mechanism of the Pore-Gate Domain.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

Evaluation of Red Blood Cell Biomechanics in the Setting of Cancer-Associated Anemia and Chemotherapy.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

ZEB1 Modifies VE-Cadherin Signaling in Lymphatic Endothelial Cells.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

Anisodamine Hydrobromide Ameliorates Pulmonary Microcirculatory Dysfunction in Septic Rats.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

The Relationship Between Sublingual Microcirculatory Structure and Frailty in Renal Transplant Candidates: Exploring Tortuosity & Endothelial Glycocalyx Biomarkers.

Microcirculation (New York, N.Y. : 1994)·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research
07:26

Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research

Published on: September 15, 2023

Microcirculation and the physiome projects.

James B Bassingthwaighte1

  • 1Department of Bioengineering, University of Washington, Washington, Seattle, USA. jbb2@washington.edu

Microcirculation (New York, N.Y. : 1994)
|December 4, 2008
PubMed
Summary
This summary is machine-generated.

The Physiome projects aim to integrate biological data and models for a comprehensive understanding of physiological functions. This effort enhances predictive approaches in medicine and physiology.

More Related Videos

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

Related Experiment Videos

Last Updated: Jun 27, 2026

Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research
07:26

Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research

Published on: September 15, 2023

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

Area of Science:

  • Physiology
  • Computational Biology
  • Systems Biology

Background:

  • The Physiome projects represent a global initiative to define the Physiome.
  • The goal is to understand integrative functions across cellular, organ, and organismal levels.
  • This involves developing databases and theoretical models.

Purpose of the Study:

  • To review the rationale and history of the Physiome projects.
  • To discuss the role of theoretical models in Physiome development.
  • To outline the current status of Physiome efforts, particularly in microcirculation.

Main Methods:

  • Developing and archiving computational models.
  • Establishing centralized databases for biological information.
  • Linking experimental data and models from diverse laboratories into cohesive frameworks.

Main Results:

  • Creation of increasingly accurate and complete models embodying quantitative biological hypotheses.
  • Establishment of public, reproducible models and curated data.
  • Advancement of integrative, analytical, and predictive approaches in physiology and medicine.

Conclusions:

  • Physiome projects are crucial for advancing integrative and predictive biological sciences.
  • High-quality, accessible data and models are essential for understanding complex physiological systems.
  • Ongoing efforts, especially in microcirculation, are contributing to a more complete Physiome.