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Updated: Jun 27, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Comparison of sublingual tablets with nitroglycerin complexed with beta-cyclodextrin or titrated with
Katarzyna Centkowska1, Małgorzata Sznitowska
1Department of Pharmaceutical Technology, Medical University of Gdańsk, 107 Gen. J. Hallera St., 80-416 Gdańsk, Poland.
Abstract:
Fast disintegrating sublingual tablets containing nitroglycerin either complexed with beta-cyclodextrin (NTG-CD) or titrated with crosspovidone (NTG-CP) were prepared using Starch 1500 or StarLac as disintegrants. Regarding disintegration time and stability of the active substance Starch 1500 was more appropriate for NTG-CD while for NTG-CP StarLac was suitable. Stability of NTG was better in NTG-CD tablets than in NTG-CP tablets, however, within 12 months of storage at 25 degrees C the loss of NTG in all formulations was still greater than 10%.
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