Related Experiment Video
Updated: Jun 27, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
Published on: February 5, 2018
Polymorphism of dextromethorphan oxidation in Polish population
Jadwiga Skretkowicz1, Anna Wojtczak, Mariola Rychlik-Sych
1Departament of Pharmacogenetics, Medical University of Lódź, 1 Muszyńskiego St., PL 90-151 Lódź, Poland.
This study determined the CYP2D6 metabolizer status in healthy Polish individuals using dextromethorphan. Poor metabolizer phenotype frequency was 9.6%, aligning with other Caucasian population data.
Area of Science:
- Pharmacogenomics
- Drug Metabolism
Background:
- Oxidation phenotype determination optimizes pharmacotherapy and explains variable drug efficacy.
- Cytochrome P450 2D6 (CYP2D6) is crucial for metabolizing many drugs.
Purpose of the Study:
- To ascertain the distribution of CYP2D6 metabolizer phenotypes in a central Polish population.
- To utilize dextromethorphan as a probe drug for assessing CYP2D6 activity.
Main Methods:
- 104 healthy Polish volunteers received an oral dose of dextromethorphan (40 mg).
- Urine was collected over 10 hours, and dextromethorphan (DM) and dextrorphan (DT) were quantified using High-Performance Liquid Chromatography (HPLC).
Main Results:
- A bimodal distribution of the dextromethorphan metabolic ratio was observed, indicating distinct oxidation phenotypes.
- The frequency of the poor metabolizer (PM) phenotype in this Polish cohort was 9.6%.
Conclusions:
- The prevalence of the PM phenotype in the studied Polish population is 9.6%.
- These findings are consistent with previous studies in Polish and other Caucasian populations regarding CYP2D6 metabolizer status.
More Related Videos
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
13:35A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
Published on: March 1, 2018
Related Concept Videos
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Pharmacogenetics of Drug Metabolism: Overview
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...