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Updated: Jun 27, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Do adaptive immune cells suppress or activate innate immunity?
Jie Zhao1, Xuanming Yang, Sogyong L Auh
1Center for Infection and Immunity and National Key Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Rd, Chaoyang District, Beijing 100101, China.
Abstract:
Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection because of the impaired ability of the innate immune system to control pathogens. Recent studies, however, reveal that adaptive immune cells actively dampen initial innate responses. In contrast to current understanding, there is now evidence that an insufficient number of T cells results in loss of control of innate immune responses. This raises new questions regarding the, as of yet underappreciated, role of the adaptive immune system in early infection and inflammation.
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