Related Experiment Video
Updated: Jun 27, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
Hepatitis B virus genotypes: natural history and implications for treatment
Man-Fung Yuen1, Ching-Lung Lai
1The University of Hong Kong, Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, China. mfyuen@hkucc.hku.hk
Abstract:
There are eight different genotypes named A-H. Genotypes have distinct geographic distribution in different regions of the world. There exists a difference in the disease profile between different genotypes. Genotype A compared with D, and B compared with C have earlier hepatitis B e-antigen seroconversion and less severe liver disease. However, genotypes are closely linked with core promoter and precore mutations. This may have a confounding effect on the association of genotypes with disease progression. Patients with genotype A compared with D and B compared with C have a better treatment response to IFN-alpha. However, there are no differences in the treatment response and rate of emergence of drug-resistant hepatitis B virus between different genotypes to nucleoside/nucleotide analog therapy.
Related Concept Videos
Hepatitis
Viral Hepatitis I: Introduction
Viruses with RNA Genomes
Genital Herpes
Inhibitors of Viral Protein Synthesis
Retrovirus Life Cycles
