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Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
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Tissue tightening technologies: fact or fiction.

Neil Sadick1

  • 1Dermatology at Weill Cornell Medical College, New York, NY, USA.

Aesthetic Surgery Journal
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

New devices combine infrared light and radiofrequency (RF) energy to safely and effectively treat skin laxity caused by aging and sun exposure. These technologies promote collagen remodeling for improved skin firmness and appearance.

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Area of Science:

  • Aesthetic dermatology
  • Biomedical engineering

Background:

  • Skin laxity is a common concern linked to aging and photodamage.
  • Current treatments like lasers and light therapies face limitations due to light scattering in the epidermis.

Purpose of the Study:

  • To review the efficacy and limitations of existing skin laxity treatments.
  • To highlight advancements in combined optical and radiofrequency (RF) energy devices.

Main Methods:

  • Review of laser, light, and RF-based technologies for skin laxity.
  • Discussion of novel devices utilizing combined infrared light and RF energy.
  • Evaluation of collagen contraction and remodeling mechanisms.

Main Results:

  • Radiofrequency (RF) energy effectively promotes collagen contraction and remodeling without epidermal scattering.
  • Combined optical and RF energy devices offer clinical benefits with reduced energy levels, pain, and adverse effects.
  • Infrared-RF devices leverage synergistic effects for enhanced skin laxity treatment.

Conclusions:

  • Combined infrared-RF devices represent a safe and effective advancement for treating skin laxity.
  • These electrooptical synergy systems demonstrate reliability and user-friendliness.
  • Further development of advanced technologies may offer additional therapeutic options.