Related Experiment Video
Updated: Jun 27, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
CO2 laser resurfacing: still a good treatment
Henry D Sandel1, Stephen W Perkins
1Department of Otolaryngology, Indiana University School of Medicine, Indianapolis, IN, USA. dansandel@gmail.com
Abstract:
The authors recommend carbon dioxide (CO(2)) laser resurfacing as an excellent tool for treatment of aging skin, especially when used for moderate to severe facial rhytids, explaining that some of the commonly cited disadvantages of this modality can be avoided with proper patient selection and conservative treatment settings. They contend that the ability to control fluence, density, and pattern size provides an excellent benefit-risk ratio. In addition, using a combination of other resurfacing modalities, such as 35% trichloroacetic acid chemical peels, 88% phenol, and dermabrasion with the CO(2) laser produces outstanding results. They cite their experience in safely and effectively performing simultaneous rhytidectomy and CO(2) laser resurfacing. Although newer technologies exist with less potential complications and downtime than the CO(2) laser, the authors point out that these modalities require multiple treatments, each with its own downtime, at a higher overall cost and with results that are arguably inferior. Here, they discuss their experience and techniques using the CO(2) laser, considering efficacy when used alone and in combination resurfacing treatments, and discuss its histology, physics, and history.

