Related Experiment Video
Updated: Jun 27, 2026

03:47
Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
CO2 laser resurfacing: still a good treatment.
Henry D Sandel1, Stephen W Perkins
1Department of Otolaryngology, Indiana University School of Medicine, Indianapolis, IN, USA. dansandel@gmail.com
Aesthetic Surgery Journal
|December 17, 2008
Summary
Carbon dioxide (CO2) laser resurfacing is effective for aging skin and facial wrinkles. Proper technique and patient selection minimize risks, offering a favorable benefit-risk ratio compared to newer, multi-treatment options.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Laser Surgery
Background:
- Aging skin and facial rhytids present significant aesthetic concerns.
- Carbon dioxide (CO2) laser resurfacing is a well-established modality for skin rejuvenation.
- Understanding the physics, histology, and history of CO2 lasers is crucial for effective application.
Purpose of the Study:
- To recommend CO2 laser resurfacing as an excellent tool for treating aging skin, particularly moderate to severe facial rhytids.
- To discuss techniques for avoiding common disadvantages through proper patient selection and conservative settings.
- To evaluate the efficacy of CO2 laser resurfacing alone and in combination with other modalities.
Main Methods:
- Review of CO2 laser physics, histology, and historical application in dermatology.
- Application of CO2 laser resurfacing with controlled fluence, density, and pattern size.
- Combination treatments including trichloroacetic acid peels, phenol peels, and dermabrasion.
Main Results:
- CO2 laser resurfacing offers an excellent benefit-risk ratio when parameters are carefully controlled.
- Combination therapies with chemical peels and dermabrasion yield outstanding results.
- Simultaneous rhytidectomy and CO2 laser resurfacing can be performed safely and effectively.
Conclusions:
- CO2 laser resurfacing remains a highly effective treatment for aging skin and facial wrinkles.
- Proper patient selection and conservative treatment settings are key to maximizing benefits and minimizing risks.
- While newer technologies exist, CO2 laser offers a cost-effective solution with arguably superior results in many cases.

