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Related Experiment Videos

[A basic study on cefpirome].

I Saito1, Y Saiko, M Yokozawa

  • 1Department of Urology, Tokyo Kyosai Hospital.

Hinyokika Kiyo. Acta Urologica Japonica
|April 1, 1991
PubMed
Summary
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Cefpirome (CPR) shows strong antibacterial activity against Neisseria gonorrhoeae. This new cephalosporin antibiotic achieves significant concentrations in human kidney and prostate tissues, suggesting its utility for urological infections.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Urology

Background:

  • Cefpirome (CPR) is a novel parenteral cephalosporin antibiotic.
  • Its efficacy against Neisseria gonorrhoeae and tissue distribution are key areas of investigation.

Purpose of the Study:

  • To evaluate the antibacterial activity of cefpirome against Neisseria gonorrhoeae.
  • To determine cefpirome concentrations in human kidney and prostate tissues.

Main Methods:

  • Minimum Inhibitory Concentrations (MICs) were determined for clinical isolates of N. gonorrhoeae.
  • Tissue concentrations were measured in patients undergoing prostate surgery and nephrectomy.

Main Results:

  • CPR demonstrated potent activity against both non-penicillinase-producing (PPNG) and PPNG strains of N. gonorrhoeae (MIC90s of 0.1 and 0.05 µg/ml, respectively).

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  • High concentrations of CPR were observed in prostate tissue, peaking at 52.8 µg/g and remaining significant for hours.
  • Kidney tissue concentrations (renal cortex and medulla) were also substantial and exceeded plasma levels.

    • Conclusions:

    • Cefpirome exhibits significant antibacterial activity against Neisseria gonorrhoeae.
    • Achieved tissue concentrations in the prostate and kidney suggest cefpirome's potential as an effective treatment for urological infections.