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Related Concept Videos

Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...

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Related Experiment Video

Updated: Jun 26, 2026

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

Tissue engineering: an option for esophageal replacement?

Augusto Zani1, Agostino Pierro, Nicola Elvassore

  • 1Department of Paediatric Surgery, Institute of Child Health & Great Ormond St Hospital, London, United Kingdom.

Seminars in Pediatric Surgery
|December 24, 2008
PubMed
Summary
This summary is machine-generated.

Esophageal tissue engineering offers a promising alternative for pediatric esophageal replacement, potentially overcoming complications associated with current surgical methods. Future research focuses on stem cells and biopolymers for functional, growing esophageal grafts.

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Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
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Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model

Published on: May 18, 2015

Area of Science:

  • Biomaterial Science
  • Regenerative Medicine
  • Pediatric Surgery

Background:

  • Esophageal replacement is crucial for pediatric conditions like long-gap esophageal atresia.
  • Current surgical techniques for esophageal replacement often lead to postoperative complications.
  • Tissue engineering presents a potential alternative to conventional methods.

Purpose of the Study:

  • To review experimental esophageal tissue engineering approaches.
  • To explore the use of biomaterials and cellularized patches.
  • To discuss future perspectives in pediatric esophageal regeneration.

Main Methods:

  • Review of studies on nonabsorbable and absorbable biomaterials for esophageal repair.
  • Analysis of research on cellularized patches for esophageal reconstruction.
  • Examination of advancements in stem cell-based tissue engineering.

Main Results:

  • Various in vitro methods for esophageal construction have been developed.
  • Both nonabsorbable and absorbable materials have been experimentally used.
  • Cellularized patches represent a significant development in esophageal regeneration.

Conclusions:

  • Esophageal tissue engineering holds promise for pediatric esophageal replacement.
  • Future strategies involve stem cells and novel biopolymers for functional grafts.
  • This approach could lead to anatomical, growth-compatible esophageal allografts.