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Pimecrolimus reduces eosinophil activation associated with calcium mobilization

Douglas A Plager1, Susan A Henke, Yoshinori Matsuwaki

  • 1Allergic Diseases Research Laboratory, Department of Dermatology, Mayo Clinic, Guggenheim 4-94, 200 First Street Southwest, Rochester, MN 55905, USA. plager.douglas@mayo.edu

International Archives of Allergy and Immunology
|January 8, 2009
PubMed
Summary

Pimecrolimus moderately inhibits eosinophil superoxide anion production and degranulation, key factors in allergic diseases like atopic dermatitis. This finding may explain its therapeutic benefits.

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