Related Experiment Video
Updated: Jun 26, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Base-pairing directed folding of a bimolecular G-quadruplex: new insights into G-quadruplex-based DNAzymes
Tao Li1, Erkang Wang, Shaojun Dong
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Abstract:
Base pairs, magic hands: An additional base-pairing duplex is utilized to control the folding topologies of a bimolecular G-quadruplex formed by two G-rich single-stranded DNAs (see picture), which is dependent on the position of base pairs. This study clearly reveals an important intrinsic role of additional base pairs in the G-quadruplex structure, and also provides a clue to the formation mechanism of the G-quadruplex-based DNAzyme.
Related Concept Videos
DNA Base Pairing
DNA Base Pairing
Single-Strand DNA Binding Proteins
Proofreading
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Proofreading
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...

